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Cardioprotective activity of iron oxide nanoparticles.


ABSTRACT: Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe2O3 nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe2O3 NPs requires the integrity of nanoparticles and is not dependent upon their surface charges and molecules that were integrated into nanoparticles. Also, Fe2O3 NPs showed no significant toxicity towards normal cardiomyocytes, indicative of their potential to treat cardiovascular diseases.

SUBMITTER: Xiong F 

PROVIDER: S-EPMC4341209 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Cardioprotective activity of iron oxide nanoparticles.

Xiong Fei F   Wang Hao H   Feng Yidong Y   Li Yunman Y   Hua Xiaoqing X   Pang Xingyun X   Zhang Song S   Song Lina L   Zhang Yu Y   Gu Ning N  

Scientific reports 20150226


Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe2O3 nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe2O3 NPs requires the integrity of nanoparticles and is not dependent upon their surface charge  ...[more]

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