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Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population.


ABSTRACT: Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis.The study was carried out in an unrelated Chinese cohort with 502 dyslexic individuals and 522 healthy controls. In all, 21 Tag SNPs covering GNPTAB, GNPTG and NAGPA were subjected to genotyping. Association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB and rs882294 in NAGPA with developmental dyslexia was identified after FDR correction for multiple comparisons.Our results revealed that the stuttering risk genes GNPTAB and NAGPA might also associate with developmental dyslexia in the Chinese population.

SUBMITTER: Chen H 

PROVIDER: S-EPMC4342093 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population.

Chen Huan H   Xu Junquan J   Zhou Yuxi Y   Gao Yong Y   Wang Guoqing G   Xia Jiguang J   Huen Michael S Y MS   Siok Wai Ting WT   Jiang Yuyang Y   Tan Li Hai LH   Sun Yimin Y  

BMC genetics 20150203


<h4>Background</h4>Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG and NAGPA with stuttering, we investigated these genes with dyslexia through association analysis.<h4>Results</h4>The study was carried out in a  ...[more]

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