Ontology highlight
ABSTRACT:
SUBMITTER: Yates LA
PROVIDER: S-EPMC4342108 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Yates Luke A LA Fleurdépine Sophie S Rissland Olivia S OS De Colibus Luigi L Harlos Karl K Norbury Chris J CJ Gilbert Robert J C RJC
Nature structural & molecular biology 20120701 8
Cytoplasmic terminal uridylyl transferases comprise a conserved family of enzymes that negatively regulate the stability or biological activity of a variety of eukaryotic RNAs, including mRNAs and tumor-suppressor let-7 microRNAs. Here we describe crystal structures of the Schizosaccharomyces pombe cytoplasmic terminal uridylyl transferase Cid1 in two apo conformers and bound to UTP. We demonstrate that a single histidine residue, conserved in mammalian Cid1 orthologs, is responsible for discrim ...[more]