Ontology highlight
ABSTRACT:
SUBMITTER: LeMasters GK
PROVIDER: S-EPMC4342329 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
LeMasters G K GK Khurana Hershey G K GK Sivaprasad U U Martin L J LJ Pilipenko V V Ericksen M B MB Burkle J W JW Lindsey M A MA Bernstein D I DI Lockey J E JE Gareri J J Lubetsky A A Koren G G Biagini Myers J M JM
The pharmacogenomics journal 20140826 2
Cotinine is a proxy for secondhand smoke (SHS) exposure. Genetic variation along nicotine and cotinine metabolic pathways may alter the internal cotinine dose, leading to misinterpretations of exposure-health outcome associations. Caucasian children with available SHS exposure and hair cotinine data were genotyped for metabolism-related genes. SHS-exposed children had 2.4-fold higher hair cotinine (0.14±0.22 ng mg(-1)) than unexposed children (0.06±0.05 ng mg(-1), P<0.001). SHS-exposed children ...[more]