Ontology highlight
ABSTRACT:
SUBMITTER: Hashemi M
PROVIDER: S-EPMC4345296 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Hashemi Mohammad M Ebrahimi Mahboubeh M Amininia Shadi S Naderi Majid M Eskandari-Nasab Ebrahim E Taheri Mohsen M
International journal of hematology-oncology and stem cell research 20141001 4
<h4>Introduction</h4>Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population.<h4>Methods</h4>This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR).<h4>Results</h4>Ou ...[more]