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Nivolumab in NSCLC: latest evidence and clinical potential.

ABSTRACT: New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.

SUBMITTER: Sundar R

PROVIDER: S-EPMC4346216 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Nivolumab in NSCLC: latest evidence and clinical potential.

Sundar Raghav R Cho Byoung-Chul BC Brahmer Julie R JR Soo Ross A RA

Therapeutic advances in medical oncology 20150301 2

New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSC ...[more]

PMID: 25755681

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