Ontology highlight
ABSTRACT:
SUBMITTER: Carrano AC
PROVIDER: S-EPMC4346368 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Carrano Andrea C AC Dillin Andrew A Hunter Tony T
Nature communications 20140508
The HECT ubiquitin E3 ligase WWP-1 is a positive regulator of lifespan in response to dietary restriction (DR) in Caenorhabditis elegans. However, substrates of WWP-1 for ubiquitylation in the DR pathway have not yet been identified. Here we identify the C. elegans Krüppel-like factor, KLF-1, as an essential and specific regulator of DR-induced longevity and a substrate for ubiquitylation by WWP-1. Knockdown of klf-1 suppresses the extended lifespan of both DR animals and wwp-1-overexpressing an ...[more]