Ontology highlight
ABSTRACT:
SUBMITTER: Schafer MJ
PROVIDER: S-EPMC4346433 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Schafer Marissa J MJ Alldred Melissa J MJ Lee Sang Han SH Calhoun Michael E ME Petkova Eva E Mathews Paul M PM Ginsberg Stephen D SD
Neurobiology of aging 20141204 3
Research indicates that female risk of developing Alzheimer's disease (AD) is greater than that of males. Moderate reduction of calorie intake, known as calorie restriction (CR), reduces pathology in AD mouse models and is a potentially translatable prevention measure for individuals at-risk for AD, as well as an important tool for understanding how the brain endogenously attenuates age-related pathology. Whether sex influences the response to CR remains unknown. In this study, we assessed the e ...[more]