Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava M
PROVIDER: S-EPMC4346627 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Srivastava Monika M Duan Guowen G Kershaw Nadia J NJ Athanasopoulos Vicki V Yeo Janet H C JH Ose Toyoyuki T Hu Desheng D Brown Simon H J SH Jergic Slobodan S Patel Hardip R HR Pratama Alvin A Richards Sashika S Verma Anil A Jones E Yvonne EY Heissmeyer Vigo V Preiss Thomas T Dixon Nicholas E NE Chong Mark M W MM Babon Jeffrey J JJ Vinuesa Carola G CG
Nature communications 20150220
Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator (Icos). When Roquin is absent or mutated (Roquin(san)), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of pre-miR-146a. Roquin also directly binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA that targets Icos mRNA. In the absence of functional Roquin, miR-1 ...[more]