Ontology highlight
ABSTRACT:
SUBMITTER: Yi R
PROVIDER: S-EPMC4346711 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Yi Rui R Poy Matthew N MN Stoffel Markus M Fuchs Elaine E
Nature 20080302 7184
In stratified epithelial tissues, homeostasis relies on the self-renewing capacity of stem cells located within the innermost basal layer. As basal cells become suprabasal, they lose proliferative potential and embark on a terminal differentiation programme. Here, we show that microRNA-203 is induced in the skin concomitantly with stratification and differentiation. By altering miR-203's spatiotemporal expression in vivo, we show that miR-203 promotes epidermal differentiation by restricting pro ...[more]