Ontology highlight
ABSTRACT:
SUBMITTER: Sag D
PROVIDER: S-EPMC4347884 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature communications 20150227
ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival. We show that reduced tumour growth in Abcg1(-/-) mice is myeloid cell intrinsic and is associated with a phenotypic shift of the macrophages from a tumour-promoting ...[more]