Ontology highlight
ABSTRACT:
SUBMITTER: Pancera M
PROVIDER: S-EPMC4348022 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Pancera Marie M Zhou Tongqing T Druz Aliaksandr A Georgiev Ivelin S IS Soto Cinque C Gorman Jason J Huang Jinghe J Acharya Priyamvada P Chuang Gwo-Yu GY Ofek Gilad G Stewart-Jones Guillaume B E GB Stuckey Jonathan J Bailer Robert T RT Joyce M Gordon MG Louder Mark K MK Tumba Nancy N Yang Yongping Y Zhang Baoshan B Cohen Myron S MS Haynes Barton F BF Mascola John R JR Morris Lynn L Munro James B JB Blanchard Scott C SC Mothes Walther W Connors Mark M Kwong Peter D PD
Nature 20141008 7523
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates, to a post-fusion state. As the sole viral antigen on the HIV-1 virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts. Here we report the structure at 3.5 Å resolution for an HIV-1 Env trimer captur ...[more]