Ontology highlight
ABSTRACT:
SUBMITTER: Moscoso CG
PROVIDER: S-EPMC4231788 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Moscoso Carlos G CG Xing Li L Hui Jinwen J Hu Jeffrey J Kalkhoran Mohammad Baikoghli MB Yenigun Onur M OM Sun Yide Y Paavolainen Lassi L Martin Loïc L Vahlne Anders A Zambonelli Carlo C Barnett Susan W SW Srivastava Indresh K IK Cheng R Holland RH
Scientific reports 20141114
Hypervariable loops of HIV-1 Env protein gp120 are speculated to play roles in the conformational transition of Env to the receptor binding-induced metastable state. Structural analysis of full-length Env-based immunogens, containing the entire V2 loop, displayed tighter association between gp120 subunits, resulting in a smaller trimeric diameter than constructs lacking V2. A prominent basal quaternary location of V2 and V3' that challenges previous reports would facilitate gp41-independent gp12 ...[more]