Ontology highlight
ABSTRACT:
SUBMITTER: Ivanov AV
PROVIDER: S-EPMC4348069 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Ivanov Alexey V AV Peng Hongzhuang H Yurchenko Vyacheslav V Yap Kyoko L KL Negorev Dmitri G DG Schultz David C DC Psulkowski Elyse E Fredericks William J WJ White David E DE Maul Gerd G GG Sadofsky Moshe J MJ Zhou Ming-Ming MM Rauscher Frank J FJ
Molecular cell 20071201 5
Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms of cooperation between these domains are unknown. We show that the PHD domain of the KAP1 corepressor functions as an intramolecular E3 ligase for sumoylation of the adjacent bromodomain. The RING finger-like structure of the PHD domain is required for both Ubc9 binding and sumoylation and directs modi ...[more]