Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration.
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ABSTRACT:
SUBMITTER: Shen H
PROVIDER: S-EPMC4349426 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration.
Shen Haowei H Kalivas Peter W PW
The international journal of neuropsychopharmacology 20121031 5
Addiction changes prefrontal cortex regulation of the nucleus accumbens, including reduced ability to induce long-term potentiation (LTP) and long-term depression (LTD). This important potential mechanism of impaired prefrontal regulation of behaviour has been shown only for cocaine. Here we show that animals trained to self-administer heroin demonstrate impaired LTP and LTD in the core of the nucleus accumbens following in vivo stimulation of the prelimbic prefrontal cortex. These data indicate ...[more]
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