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The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy.

ABSTRACT: No matter how many times one explores the structure of the myosin molecule, there is always something new to discover. Here, I describe the myosin mesa, a structural feature of the motor domain that has the characteristics of a binding domain for another protein, possibly myosin-binding protein C (MyBP-C). Interestingly, many well-known hypertrophic cardiomyopathy (HCM) mutations lie along this surface and may affect the putative interactions proposed here. A potential unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy is discussed here. It involves increased power output of the cardiac muscle as a result of HCM mutations causing the release of inhibition by myosin binding protein C.

SUBMITTER: Spudich JA

PROVIDER: S-EPMC4349527 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy.

Spudich James A JA

Biochemical Society transactions 20150201 1

No matter how many times one explores the structure of the myosin molecule, there is always something new to discover. Here, I describe the myosin mesa, a structural feature of the motor domain that has the characteristics of a binding domain for another protein, possibly myosin-binding protein C (MyBP-C). Interestingly, many well-known hypertrophic cardiomyopathy (HCM) mutations lie along this surface and may affect the putative interactions proposed here. A potential unifying hypothesis for th ...[more]

PMID: 25619247

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