Ontology highlight
ABSTRACT:
SUBMITTER: Spudich JA
PROVIDER: S-EPMC6475635 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Pflugers Archiv : European journal of physiology 20190215 5
Several lines of evidence suggest that the primary effect of hypertrophic cardiomyopathy mutations in human β-cardiac myosin is hypercontractility of the heart, which leads to subsequent hypertrophy, fibrosis, and myofilament disarray. Here, I describe three perspectives on the molecular basis of this hypercontractility. The first is that hypercontractility results from changes in the fundamental parameters of the actin-activated β-cardiac myosin chemo-mechanical ATPase cycle. The second conside ...[more]