Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC4350020 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Li Ping P Ruan Xiangbo X Yang Ling L Kiesewetter Kurtis K Zhao Yi Y Luo Haitao H Chen Yong Y Gucek Marjan M Zhu Jun J Cao Haiming H
Cell metabolism 20150301 3
Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a marked reduction in plasma triglyceride levels. We show that lncLSTR depletion enhances apoC2 expression, leading to robust lipoprotein lipase activation and increased plasma trigl ...[more]