Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC5370442 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Li Duan D Cheng Min M Niu Yuqiang Y Chi Xiaojing X Liu Xiuying X Fan Jingjing J Fan Heng H Chang Yongsheng Y Yang Wei W
International journal of biological sciences 20170225 3
Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis. Aberrant expression of SREBPs frequently leads to lipid metabolism dysregulation. Long non-coding RNAs (lncRNAs) have been identified with diverse biological functions, but the effects of lncRNAs on lipid metabolism are rarely reported. Here, we identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibited expression of SRE ...[more]