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NF-?B and STAT3 in glioblastoma: therapeutic targets coming of age.


ABSTRACT: Since we last addressed the roles of NF-?B and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-?B and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-?B and STAT3 signaling, the ways in which these pathways contribute to GBM and advances in preclinical and clinical targeting of these two signaling cascades.

SUBMITTER: Gray GK 

PROVIDER: S-EPMC4350260 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.

Gray G Kenneth GK   McFarland Braden C BC   Nozell Susan E SE   Benveniste Etty N EN  

Expert review of neurotherapeutics 20140929 11


Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-κB and STAT3 signaling, the wa  ...[more]

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