NF-?B and STAT3 in glioblastoma: therapeutic targets coming of age.
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ABSTRACT:
SUBMITTER: Gray GK
PROVIDER: S-EPMC4350260 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.
Gray G Kenneth GK McFarland Braden C BC Nozell Susan E SE Benveniste Etty N EN
Expert review of neurotherapeutics 20140929 11
Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-κB and STAT3 signaling, the wa ...[more]
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