Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
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ABSTRACT:
SUBMITTER: Schweiger MW
PROVIDER: S-EPMC7718424 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
Schweiger Markus W MW Li Mao M Giovanazzi Alberta A Fleming Renata L RL Tabet Elie I EI Nakano Ichiro I Würdinger Thomas T Chiocca Ennio Antonio EA Tian Tian T Tannous Bakhos A BA
Advanced biosystems 20200609 12
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal treatment, long-term survival remains uncommon. GBM can be roughly divided into three different molecular subtypes, each varying in aggressiveness and treatment resistance. Recent evidence shows plasticity between these subtypes in which the proneural (PN) glioma stem-like cells (GSCs) undergo transition into the more aggressive mesenchymal (MES) subtype, leading to therapeutic resistance. Extracellular vesic ...[more]
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