Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4350265 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Wang Yizhong Y Li Jieliang J Wang Xu X Zhou Yu Y Zhang Ting T Ho Wenzhe W
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20140930 3
Lambda-interferons (IFN-λs) have been demonstrated as having the ability to inhibit HIV replication in macrophages. However, specific differences in signaling transduction and anti-HIV activity in macrophages between different IFN-λs are unclear. Here, we showed that although all 3 members of (IFN-λ1, λ2, and λ3) IFN-λ family induced the expression of a number of genes of janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway in monocyte-derived macrophages, ...[more]