Ontology highlight
ABSTRACT:
SUBMITTER: Lee C
PROVIDER: S-EPMC4350682 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20150301 3
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA. Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin se ...[more]