Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC6640593 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kim Su-Jeong SJ Miller Brendan B Mehta Hemal H HH Xiao Jialin J Wan Junxiang J Arpawong Thalida E TE Yen Kelvin K Cohen Pinchas P
Physiological reports 20190701 13
MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice. Although plasma markers are good markers for the metabolic condition, whether MOTS-c changes plasma markers in diet-induced obese mice has not been examined. Here, we used an unbiased metabolomics approach to examine the effect of MOTS-c on plasma markers of metabolic dysfunction. We found that three pathways - sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism - we ...[more]