Ontology highlight
ABSTRACT:
SUBMITTER: Benskey MJ
PROVIDER: S-EPMC4351472 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Benskey Matthew J MJ Kuhn Nathan C NC Galligan James J JJ Garcia Joanna J Boye Shannon E SE Hauswirth William W WW Mueller Christian C Boye Sanford L SL Manfredsson Fredric P FP
Molecular therapy : the journal of the American Society of Gene Therapy 20150116 3
Recombinant adeno-associated virus (AAV) vectors are one of the most widely used gene transfer systems in research and clinical trials. AAV can transduce a wide range of biological tissues, however to date, there has been no investigation on targeted AAV transduction of the enteric nervous system (ENS). Here, we examined the efficiency, tropism, spread, and immunogenicity of AAV transduction in the ENS. Rats received direct injections of various AAV serotypes expressing green fluorescent protein ...[more]