LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis.
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ABSTRACT:
SUBMITTER: De Araujo ES
PROVIDER: S-EPMC4352068 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis.
De Araújo Érica S S ÉS Kashiwabara André Y AY Achatz Maria I W MI Moredo Luciana F LF De Sá Bianca C S BC Duprat João P JP Rosenberg Carla C Carraro Dirce M DM Krepischi Ana C V AC
Melanoma research 20150401 2
Aberrant DNA methylation pattern is a well-known epigenetic marker of cancer cells. Recently, aberrant methylation was also reported in the peripheral blood of cancer patients and it could potentially serve as a biomarker for cancer risk. We investigated the methylation pattern of LINE-1 and other repetitive DNA elements in peripheral blood of cutaneous melanoma patients in order to search for an association with clinical characteristics. The patient cohort was composed by 69 unrelated melanoma ...[more]
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