Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.
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ABSTRACT:
SUBMITTER: Dunkel Y
PROVIDER: S-EPMC6303298 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.
Dunkel Ying Y Reid Anna L AL Ear Jason J Aznar Nicolas N Millward Michael M Gray Elin E Pearce Robert R Ziman Melanie M Ghosh Pradipta P
Scientific reports 20181221 1
A loss of balance between G protein activation and deactivation has been implicated in the initiation of melanomas, and non-canonical Wnt signaling via the Wnt5A/Frizzled (FZD) pathway has been shown to be critical for the switch to an invasive phenotype. Daple [CCDC88C], a cytosolic guanine nucleotide exchange modulator (GEM) which enhances non-canonical Wnt5A/FZD signaling via activation of trimeric G protein, Gαi, has been shown to serve opposing roles-as an inducer of EMT and invasiveness an ...[more]
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