Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.
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ABSTRACT:
SUBMITTER: Guillot-Sestier MV
PROVIDER: S-EPMC4352138 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.
Guillot-Sestier Marie-Victoire MV Doty Kevin R KR Gate David D Rodriguez Javier J Leung Brian P BP Rezai-Zadeh Kavon K Town Terrence T
Neuron 20150122 3
The impact of inflammation suppressor pathways on Alzheimer's disease (AD) evolution remains poorly understood. Human genetic evidence suggests involvement of the cardinal anti-inflammatory cytokine, interleukin-10 (IL10). We crossed the APP/PS1 mouse model of cerebral amyloidosis with a mouse deficient in Il10 (APP/PS1(+)Il10(-/-)). Quantitative in silico 3D modeling revealed activated Aβ phagocytic microglia in APP/PS1(+)Il10(-/-) mice that restricted cerebral amyloidosis. Genome-wide RNA sequ ...[more]
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