Ontology highlight
ABSTRACT:
SUBMITTER: Pinto EM
PROVIDER: S-EPMC4352712 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nature communications 20150306
Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal chromosome. IGF2 on chromosome 11p is overexpressed in 100% of the tumours. TP53 mutations and chromosome 17 LOH with selection against wild-type TP53 are observed in 28 ACTs (76%). Chromosomes 11p ...[more]