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Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012.


ABSTRACT: Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.

SUBMITTER: Memish ZA 

PROVIDER: S-EPMC4353318 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012.

Memish Ziad A ZA   Alsahly Ahmad A   Masri Malak Al MA   Heil Gary L GL   Anderson Benjamin D BD   Peiris Malik M   Khan Salah Uddin SU   Gray Gregory C GC  

Influenza and other respiratory viruses 20141203 2


Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutral  ...[more]

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