Centromeric binding and activity of Protein Phosphatase 4.
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ABSTRACT:
SUBMITTER: Lipinszki Z
PROVIDER: S-EPMC4354016 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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Centromeric binding and activity of Protein Phosphatase 4.
Lipinszki Zoltan Z Lefevre Stephane S Savoian Matthew S MS Singleton Martin R MR Glover David M DM Przewloka Marcin R MR
Nature communications 20150106
The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic subunits to their sites of action. Phosphoprotein phosphatase 4 (PP4) has been recently shown to participate in the regulation of cell cycle progression. We now find that the EVH1 domain of the regulat ...[more]
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