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Osmotic pressure induced tensile forces in tendon collagen.

ABSTRACT: Water is an important component of collagen in tendons, but its role for the function of this load-carrying protein structure is poorly understood. Here we use a combination of multi-scale experimentation and computation to show that water is an integral part of the collagen molecule, which changes conformation upon water removal. The consequence is a shortening of the molecule that translates into tensile stresses in the range of several to almost 100?MPa, largely surpassing those of about 0.3?MPa generated by contractile muscles. Although a complete drying of collagen would be relevant for technical applications, such as the fabrication of leather or parchment, stresses comparable to muscle contraction already occur at small osmotic pressures common in biological environments. We suggest, therefore, that water-generated tensile stresses may play a role in living collagen-based materials such as tendon or bone.

SUBMITTER: Masic A

PROVIDER: S-EPMC4354200 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Osmotic pressure induced tensile forces in tendon collagen.

Masic Admir A Bertinetti Luca L Schuetz Roman R Chang Shu-Wei SW Metzger Till Hartmut TH Buehler Markus J MJ Fratzl Peter P

Nature communications 20150122

Water is an important component of collagen in tendons, but its role for the function of this load-carrying protein structure is poorly understood. Here we use a combination of multi-scale experimentation and computation to show that water is an integral part of the collagen molecule, which changes conformation upon water removal. The consequence is a shortening of the molecule that translates into tensile stresses in the range of several to almost 100 MPa, largely surpassing those of about 0.3 ...[more]

PMID: 25608644

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