Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC454384 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Ge Xuecai X Hannan Frances F Xie Zuolei Z Feng Chunhua C Tully Tim T Zhou Haimeng H Xie Zuoping Z Zhong Yi Y Zhong Yi Y
Proceedings of the National Academy of Sciences of the United States of America 20040625 27
Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, ne ...[more]