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Notch signaling in Drosophila long-term memory formation.

ABSTRACT: Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, neither learning nor early memory were affected. Furthermore, induced overexpression of a wild-type (normal) N transgene specifically enhanced LTM formation. These experiments demonstrate that N signaling contributes to LTM formation in the Drosophila adult brain.

SUBMITTER: Ge X

PROVIDER: S-EPMC454384 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature

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Notch signaling in Drosophila long-term memory formation.

Ge Xuecai X Hannan Frances F Xie Zuolei Z Feng Chunhua C Tully Tim T Zhou Haimeng H Xie Zuoping Z Zhong Yi Y Zhong Yi Y

Proceedings of the National Academy of Sciences of the United States of America 20040625 27

Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, ne ...[more]

PMID: 15220476

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