Polymorphisms in the IFN?, IL-10, and TGF? genes may be associated with HIV-1 infection.

ABSTRACT: This study investigated possible associations between the TNF?-308G/A, IFN+874A/T, IL-6-174C/G, IL-10-1082A/G, and TGF?-509C/T polymorphisms with HIV-1 infection, in addition to correlation of the polymorphisms with clinical markers of AIDS progression, such as levels of CD4+/CD8+ T lymphocytes and plasma viral load.A total of 216 individuals who were infected with HIV-1 and on antiretroviral therapy (ART) and 294 individuals from the uninfected control group were analyzed.All individuals evaluated were negative for total anti-HBc, anti-HCV, anti-T. pallidum, and anti-HTLV-1/2. The polymorphisms were identified by PCR-RFLP. Individuals presenting the IFN+874A allele as well as the AA genotype were more frequent in the HIV-1 infected group compared to the control group (P < 0.05), in addition to having lower levels of CD4+ T lymphocytes. The CD8+ T lymphocytes count was significantly lower in individuals with the IL-10-1082 GG genotype. The TGF?-509TT genotype was associated with higher plasma viral load.The results suggest that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4+ T lymphocytes. In addition, the genotype associated with high serum levels of TGF? may be associated with an increase in plasma viral load.

SUBMITTER: Freitas FB 

PROVIDER: S-EPMC4354727 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature