IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.
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ABSTRACT:
SUBMITTER: Su QJ
PROVIDER: S-EPMC6286684 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.
Su Qi-Jian QJ Wang Xu X Zhou Run-Hong RH Guo Le L Liu Hang H Li Jie-Liang JL Ho Wen-Zhe WZ
Scandinavian journal of immunology 20181010 5
The recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. This IFN-λ4-mediated HIV inhibition was compromised by the antibodies against IFN-λ receptor complex, IFN-λR1/IL-10R2. IFN-λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon-stimulated genes. These findings indicated that IFN-λ4 can inhibit HI ...[more]
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