Causes and consequences of replication stress.
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ABSTRACT:
SUBMITTER: Zeman MK
PROVIDER: S-EPMC4354890 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Causes and consequences of replication stress.
Zeman Michelle K MK Cimprich Karlene A KA
Nature cell biology 20140101 1
Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this resp ...[more]
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