Copper signalling: causes and consequences.
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ABSTRACT:
SUBMITTER: Kardos J
PROVIDER: S-EPMC6198518 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Copper signalling: causes and consequences.
Kardos Julianna J Héja László L Simon Ágnes Á Jablonkai István I Kovács Richard R Jemnitz Katalin K
Cell communication and signaling : CCS 20181022 1
Copper-containing enzymes perform fundamental functions by activating dioxygen (O<sub>2</sub>) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O<sub>2</sub> transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambien ...[more]
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