Ontology highlight
ABSTRACT:
SUBMITTER: Litvin O
PROVIDER: S-EPMC4355234 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Litvin Oren O Schwartz Sarit S Wan Zhenmao Z Schild Tanya T Rocco Mark M Oh Nul Loren NL Chen Bo-Juen BJ Goddard Noel N Pratilas Christine C Pe'er Dana D
Molecular cell 20150212 5
Drugs that inhibit the MAPK pathway have therapeutic benefit in melanoma, but responses vary between patients, for reasons that are still largely unknown. Here we aim at explaining this variability using pre- and post-MEK inhibition transcriptional profiles in a panel of melanoma cell lines. We found that most targets are context specific, under the influence of the pathway in only a subset of cell lines. We developed a computational method to identify context-specific targets, and found differe ...[more]