Ontology highlight
ABSTRACT:
SUBMITTER: Dalby AB
PROVIDER: S-EPMC4355236 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Journal of molecular biology 20150123 6 Pt B
Telomere maintenance is a highly coordinated process, and its misregulation is linked to cancer and telomere-shortening syndromes. Recent studies have shown that the TEL-patch--a cluster of amino acids on the surface of the shelterin component TPP1--is necessary for the recruitment of telomerase to the telomere in human cells. However, there has been only basic biochemical analysis of the role of TPP1 in the telomerase recruitment process. Here we develop an in vitro assay to quantitatively meas ...[more]