Ontology highlight
ABSTRACT:
SUBMITTER: Pike AM
PROVIDER: S-EPMC6791651 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20191011 21
TIN2 is an important regulator of telomere length, and mutations in <i>TINF2</i>, the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we tested the effects of human TIN2 on telomerase activity. We identified a new isoform in human cells, TIN2M, that is expressed at levels similar to those of previously studied TIN2 isoforms. All three TIN2 isoforms localized ...[more]