Sirtuin inhibitor sirtinol is an intracellular iron chelator.
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ABSTRACT:
SUBMITTER: Gautam R
PROVIDER: S-EPMC4355247 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Sirtuin inhibitor sirtinol is an intracellular iron chelator.
Gautam R R Akam E A EA Astashkin A V AV Loughrey J J JJ Tomat E E
Chemical communications (Cambridge, England) 20150301 24
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. ...[more]
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