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Sirtuin inhibitor sirtinol is an intracellular iron chelator.

ABSTRACT: Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

SUBMITTER: Gautam R 

PROVIDER: S-EPMC4355247 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Sirtuin inhibitor sirtinol is an intracellular iron chelator.

Gautam R R   Akam E A EA   Astashkin A V AV   Loughrey J J JJ   Tomat E E  

Chemical communications (Cambridge, England) 20150301 24

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. ...[more]

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