Ontology highlight
ABSTRACT:
SUBMITTER: Kawatani M
PROVIDER: S-EPMC5138588 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kawatani Makoto M Muroi Makoto M Wada Akira A Inoue Gyo G Futamura Yushi Y Aono Harumi H Shimizu Kenshirou K Shimizu Takeshi T Igarashi Yasuhiro Y Takahashi-Ando Naoko N Osada Hiroyuki H
Scientific reports 20161206
Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report the identification of the molecular target of CMA by ChemProteoBase, a proteome-based approach for drug target identification. ChemProteoBase profiling showed that CMA is closely clustered with di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone, an iron chelator. CMA bound to both Fe(II) and Fe(III) ions and formed a 2:1 chelator-iron c ...[more]