Ontology highlight
ABSTRACT:
SUBMITTER: Pinard MA
PROVIDER: S-EPMC4355338 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Pinard Melissa A MA Mahon Brian B McKenna Robert R
BioMed research international 20150224
The alpha carbonic anhydrases (α-CAs) are a group of structurally related zinc metalloenzymes that catalyze the reversible hydration of CO2 to HCO3(-). Humans have 15 different α-CAs with numerous physiological roles and expression patterns. Of these, 12 are catalytically active, and abnormal expression and activities are linked with various diseases, including glaucoma and cancer. Hence there is a need for CA isoform specific inhibitors to avoid off-target CA inhibition, but due to the high ami ...[more]