Ontology highlight
ABSTRACT:
SUBMITTER: Pinard MA
PROVIDER: S-EPMC4601603 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Pinard Melissa A MA Aggarwal Mayank M Mahon Brian P BP Tu Chingkuang C McKenna Robert R
Acta crystallographica. Section F, Structural biology communications 20150923 Pt 10
Human carbonic anhydrase (CA; EC 4.2.1.1) isoform IX (CA IX) is an extracellular zinc metalloenzyme that catalyzes the reversible hydration of CO2 to HCO3(-), thereby playing a role in pH regulation. The majority of normal functioning cells exhibit low-level expression of CA IX. However, in cancer cells CA IX is upregulated as a consequence of a metabolic transition known as the Warburg effect. The upregulation of CA IX for cancer progression has drawn interest in it being a potential therapeuti ...[more]