Ontology highlight
ABSTRACT:
SUBMITTER: Elavazhagan S
PROVIDER: S-EPMC4355383 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Elavazhagan Saranya S Fatehchand Kavin K Santhanam Vikram V Fang Huiqing H Ren Li L Gautam Shalini S Reader Brenda B Mo Xiaokui X Cheney Carolyn C Briercheck Edward E Vasilakos John P JP Dietsch Gregory N GN Hershberg Robert M RM Caligiuri Michael M Byrd John C JC Butchar Jonathan P JP Tridandapani Susheela S
Journal of immunology (Baltimore, Md. : 1950) 20150209 6
FcγRs are critical mediators of mAb cancer therapies, because they drive cytotoxic processes upon binding of effector cells to opsonized targets. Along with NK cells, monocytes are also known to destroy Ab-coated targets via Ab-dependent cellular cytotoxicity (ADCC). However, the precise mechanisms by which monocytes carry out this function have remained elusive. In this article, we show that human monocytes produce the protease granzyme B upon both FcγR and TLR8 activation. Treatment with TLR8 ...[more]