Ontology highlight
ABSTRACT:
SUBMITTER: Khanna V
PROVIDER: S-EPMC7870826 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Khanna Vidhi V Kim Hyunjoon H Zhang Wenqiu W Larson Peter P Shah Manan M Griffith Thomas S TS Ferguson David D Panyam Jayanth J
Scientific reports 20210208 1
There is a significant interest in designing therapeutic agents that can enhance ADCC and thereby improve clinical responses with approved antibodies. We recently reported the combination of an imidazoquinoline-based TLR7/8 agonist (522) with a monoclonal antibody improved ADCC in vitro and in vivo. In the present study, we tested several new small molecule TLR7/8 agonists that induce significantly higher cytokines compared to both the FDA-approved TLR7 agonist, imiquimod, and 522. We evaluated ...[more]