Ontology highlight
ABSTRACT:
SUBMITTER: Ju JH
PROVIDER: S-EPMC4356337 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ju J-h JH Oh S S Lee K-m KM Yang W W Nam K S KS Moon H-G HG Noh D-Y DY Kim C G CG Park G G Park J B JB Lee T T Arteaga C L CL Shin I I
Cell death and differentiation 20141024 4
Cytokeratin19 (KRT19) is widely used as a biomarker for the detection of disseminated tumors. Using an LC-MS/MS proteomics approach, we found that KRT19 was upregulated in HER2-overexpressing cells and tissues. KRT19 expression was induced by HER2-downstream ERK at the transcriptional level. Another HER2-downstream kinase, Akt, was found to phosphorylate KRT19 on Ser35 and induce membrane translocation of KRT19 and remodeling of KRT19 from filamentous to granulous form. KRT19 phosphorylated by A ...[more]