Ontology highlight
ABSTRACT:
SUBMITTER: Matsuzaki T
PROVIDER: S-EPMC6215420 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Matsuzaki Tomoko T Kitayama Hitoshi H Omura Akira A Nishimoto Emi E Alexander David B DB Noda Makoto M
Biology open 20181004 10
The tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), NOTCH-signaling and WNT7-signaling. It remains unclear, however, how broad the spectrum of RECK targets extends. To find novel RECK binding partners, we took the unbiased approach of yeast two-hybrid screening. This approach detected ADAMTS10 as a RECK-interactor. ADAMTS10 has been characterized as a metalloproteinase involved in fibrillin-rich microfibril biogenesis, and its mutations ha ...[more]