The structure of the hexameric atrazine chlorohydrolase AtzA.
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ABSTRACT:
SUBMITTER: Peat TS
PROVIDER: S-EPMC4356373 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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The structure of the hexameric atrazine chlorohydrolase AtzA.
Peat T S TS Newman J J Balotra S S Lucent D D Warden A C AC Scott C C
Acta crystallographica. Section D, Biological crystallography 20150226 Pt 3
Atrazine chlorohydrolase (AtzA) was discovered and purified in the early 1990s from soil that had been exposed to the widely used herbicide atrazine. It was subsequently found that this enzyme catalyzes the first and necessary step in the breakdown of atrazine by the soil organism Pseudomonas sp. strain ADP. Although it has taken 20 years, a crystal structure of the full hexameric form of AtzA has now been obtained. AtzA is less well adapted to its physiological role (i.e. atrazine dechlorinatio ...[more]
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