Ontology highlight
ABSTRACT:
SUBMITTER: Sattelle BM
PROVIDER: S-EPMC4356732 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Sattelle Benedict M BM Shakeri Javad J Cliff Matthew J MJ Almond Andrew A
Biomacromolecules 20150216 3
Proteoglycan spatiotemporal organization underpins extracellular matrix biology, but atomic scale glimpses of this microarchitecture are obscured by glycosaminoglycan size and complexity. To overcome this, multimicrosecond aqueous simulations of chondroitin and dermatan sulfates were abstracted into a prior coarse-grained model, which was extended to heterogeneous glycosaminoglycans and small leucine-rich proteoglycans. Exploration of relationships between sequence and shape led to hypotheses th ...[more]